Research

Photo of doctor listening to patient

Researchers at the MGH Depression Clinical and Research Program are working to advance the understanding and treatment of depression.

Many of our current research studies are actively recruiting patients to team up with us to improve depression care.

Contact our caring, expert staff to explore what options may be best for you, or find available studies now.

Studies

Scroll down to see all studies or select the studies you want to see and click "Apply my choice(s)."

Alternative treatments

Past research indicates that one session of whole-body hyperthermia (WBH), which involves whole-body heating in a sauna-like environment, can lead to a significant improvement in depressive symptoms. 

Psychotherapy

The purpose of this study is to understand how to best treat adults with depression using Cognitive Behavioral Therapy (or CBT). 

Mental health and technology

Are you currently depressed? Have you recently started treatment with medications or therapy? Do you own a smart phone? If so, you may be eligible to participate in a virtual research study at Massachusetts General Hospital (MGH).

The purpose of this study is to determine whether playing a mobile phone game designed to help people think in a more global and creative way can reduce symptoms of depression.

Biological and genetic research

Past research indicates that one session of whole-body hyperthermia (WBH), which involves whole-body heating in a sauna-like environment, can lead to a significant improvement in depressive symptoms. 

Do you have Medicare and are you struggling to find a depression treatment that works? The RECOVER VNS trial is a 5-year-long clinical trial intended to determine if Medicare patients suffering with treatment-resistant depression experience an antidepressant benefit from implantation with a vagus nerve stimulator. 

Are you currently receiving Ketamine infusions at the MGH Intravenous Ketamine Clinic for Depression? You may qualify to be a part of our study!

Medication

The KETAMIND Study aims to examine the effect of ketamine and esketamine treatments in reducing depressive symptoms and suicidal ideation, and whether improvement continues over the course of 6 months.

Are you currently receiving Ketamine infusions at the MGH Intravenous Ketamine Clinic for Depression? You may qualify to be a part of our study!

Neuroimaging

Are you currently receiving Ketamine infusions at the MGH Intravenous Ketamine Clinic for Depression? You may qualify to be a part of our study!