Augmentation versus Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders with Treatment Resistant Depression (ASCERTAIN-TRD)

Photo of two researchers talking together

Depression treatments that are available today are the result of decades of research.

The purpose of this research study is to compare the effect of augmenting an antidepressant with aripiprazole (common brand Abilify) or rTMS (commonly referred to as Repetitive transcranial magnetic stimulation) versus switching to venlafaxine XR (common brand Effexor) for participants who have tried an antidepressant in the past but has not helped their depression. You must already be on an antidepressant medication, but it isn’t working very well.  For more information, please contact Regina at 617-724-2936 or at

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