Our studies

Photo of two researchers talking together

Depression treatments that are available today are the result of decades of research.

Researchers at the MGH Depression Clinical and Research Program are working to advance the understanding and treatment of depression.

Many of our current research studies are actively recruiting patients to team up with us to improve depression care.

Contact our caring, expert staff to explore what options may be best for you, or find available studies now.

Studies

Scroll down to see all studies or select the studies you want to see and click "Apply my choice(s)."

Alternative treatments

Are you depressed, sad or blue? Interested in trying mindfulness meditation or relaxation methods? The Massachusetts General Hospital is conducting a clinical research study evaluating the effects on the brain of two different 8-week programs for people suffering from depression.

Are you overweight and feeling down? If so, you may be able to participate in a research study at the Massachusetts General Hospital in Boston investigating the benefits of Omega-3 Fatty Acids in treating Major Depression.

You may be eligible to participate in a research study using Transcranial LED Therapy (TLT) to treat depression that is being conducted at Massachusetts General Hospital.

Have you been feeling down or depressed? Do you no longer enjoy the things you used to? Are you interested in finding a new way to treat your depression? If so, you may be eligible to participate in a new research study using hyperthermic yoga to treat depression. 

Psychotherapy

Are you depressed, sad or blue? Interested in trying mindfulness meditation or relaxation methods? The Massachusetts General Hospital is conducting a clinical research study evaluating the effects on the brain of two different 8-week programs for people suffering from depression.

The purpose of this study is to develop an adapted version of Cognitive-Behavioral Therapy (or CBT) specifically for individuals diagnosed with depression and have sustained a moderate to severe traumatic brain injury (or TBI). 

Mental health and technology

Are you currently depressed? Are you currently being treated for depression with medications or therapy? Do you own an Android phone? If so, you may be eligible to participate at no cost to you in a research study at Massachusetts General Hospital (MGH).

The purpose of this study is to develop an adapted version of Cognitive-Behavioral Therapy (or CBT) specifically for individuals diagnosed with depression and have sustained a moderate to severe traumatic brain injury (or TBI). 

Biological and genetic research

Have you been feeling sad, blue, or down? Have you lost interest in activities you normally enjoy?
 
McLean Hospital and MGH researchers are looking for volunteers to understand the role of dopamine, a chemical that is naturally released by brain cells, in emotions and behavior. Participating in this study will take up to 14 hours. For your time, you will receive up to $731.
 
We are seeking adults who are between the ages of 18-45 years old, right-handed, and not currently taking any prescription drugs for depression, anxiety, or ADHD.
 
If you are interested in participating, please contact Lindsey at 617-724-7244 or sboyden@partners.org. Please include your phone number and some good times to reach you, and researchers will contact you to conduct a preliminary phone screen and to provide more information about the study.

Medication

Have you been feeling down, depressed, or hopeless? You may be eligible to participate in a research study at Massachusetts General Hospital. We are studying the brain chemistry of people who get better taking an FDA approved antidepressant medication and people who get better taking a placebo.

In this study, you will receive vortioxetine (a medication approved for the treatment of depression) for 6 weeks.

Are you currently struggling with depression? Have you been unable to find relief with standard antidepressant medication? The Depression Clinical and Research Program at Massachusetts General Hospital is seeking patients with major depressive disorder (MDD) between the ages of 18 and 65 to participate in a new depression research study. This study is testing whether the combination of the drugs brexpiprazole and intranasal ketamine can safely and effectively treat people who are already taking an antidepressant medication, but have not had a satisfactory response.

Neuroimaging

Have you been feeling down, depressed, or hopeless? You may be eligible to participate in a research study at Massachusetts General Hospital. We are studying the brain chemistry of people who get better taking an FDA approved antidepressant medication and people who get better taking a placebo.

Have you been feeling sad, blue, or down? Have you lost interest in activities you normally enjoy?
 
McLean Hospital and MGH researchers are looking for volunteers to understand the role of dopamine, a chemical that is naturally released by brain cells, in emotions and behavior. Participating in this study will take up to 14 hours. For your time, you will receive up to $731.
 
We are seeking adults who are between the ages of 18-45 years old, right-handed, and not currently taking any prescription drugs for depression, anxiety, or ADHD.
 
If you are interested in participating, please contact Lindsey at 617-724-7244 or sboyden@partners.org. Please include your phone number and some good times to reach you, and researchers will contact you to conduct a preliminary phone screen and to provide more information about the study.