Research

Photo of doctor listening to patient

Researchers at the MGH Depression Clinical and Research Program are working to advance the understanding and treatment of depression.

Many of our current research studies are actively recruiting patients to team up with us to improve depression care.

Contact our caring, expert staff to explore what options may be best for you, or find available studies now.

Studies

Scroll down to see all studies or select the studies you want to see and click "Apply my choice(s)."

Alternative treatments

Are you caring for a relative with Dementia? Do you want to improve your mood, outlook, or energy? You may be eligible for a short-term group therapy research study.

Are you currently struggling with depression? We are doing a research study to find out if
using xenon could be helpful for people with Major Depression and Bipolar Depression who
have not responded to the usual medications or combination of medications.

Psychotherapy

The purpose of this study is to develop an adapted version of Cognitive-Behavioral Therapy (or CBT) specifically for individuals diagnosed with depression and have sustained a moderate to severe traumatic brain injury (or TBI). 

Are you caring for a relative with Dementia? Do you want to improve your mood, outlook, or energy? You may be eligible for a short-term group therapy research study.

Mental health and technology

The purpose of this study is to develop an adapted version of Cognitive-Behavioral Therapy (or CBT) specifically for individuals diagnosed with depression and have sustained a moderate to severe traumatic brain injury (or TBI). 

Are you currently struggling with depression? We are doing a research study to find out if
using xenon could be helpful for people with Major Depression and Bipolar Depression who
have not responded to the usual medications or combination of medications.

Are you currently depressed? Have you recently started treatment with medications or therapy? Do you own a smart phone? If so, you may be eligible to participate in a virtual research study at Massachusetts General Hospital (MGH).

Medication

Have you been feeling down, depressed, or hopeless? You may be eligible to participate in a research study at Massachusetts General Hospital. We are studying the brain chemistry of people who get better taking an FDA approved antidepressant medication and people who get better taking a placebo.

Neuroimaging

Have you been feeling down, depressed, or hopeless? You may be eligible to participate in a research study at Massachusetts General Hospital. We are studying the brain chemistry of people who get better taking an FDA approved antidepressant medication and people who get better taking a placebo.